KASSIS LABORATORY

PUBLICATION LIST

 

 

Sgouros G, Knox SJ, Joiner MC, Morgan WF, Kassis AI. MIRD continuing education: Bystander and low–dose-rate effects: are these relevant to radionuclide therapy? J Nucl Med 2007; 48:1683-91. 

Singh A, Chen K, Adelstein SJ, Kassis AI. Synthesis of coumarin–polyamine-based molecular probe for the detection of hydroxyl radicals generated by gamma radiation. Radiat Res 2007; 168:233-42.

Wang K, Kirichian AM, Al Aowad AF, Adelstein SJ, Kassis AI. Evaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative. Bioconjugate Chem 2007; 18:754-64.

Chen K, Al Aowad AF, Adelstein SJ, Kassis AI. Molecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs. J Med Chem 2007; 50:663-73.

Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors. Cancer Res 2007; 67:2197-205.

Yasui LS, Chen K, Wang K, Jones TP, Caldwell J, Guse D, Kassis AI. Using Hoechst 33342 to target radioactivity to the cell nucleus. Radiat Res 2007; 167:167-75.

Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI. Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with g-ray exposure. Nucl Med Biol 2006; 33:1055-63.

Chen K, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI. In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase–mediated cancer diagnosis and therapy. Mol Cancer Ther 2006; 5:3001-13.

Balagurumoorthy P, Chen K, Bash RC, Adelstein SJ, Kassis AI. Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst. Radiat Res 2006; 166:333-44.

Pospisil P, Iyer LK, Adelstein SJ, Kassis AI. A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics 2006; 7:354.

Wang K, Adelstein SJ, Kassis AI. Radiotracer-based method for determining water solubility of highly insoluble compounds. J Labelled Comp Radiopharm 2006; 49:773-88.

Kishikawa H, Wang K, Adelstein SJ, Kassis AI. Inhibitory and stimulatory bystander effects are differentially induced by iodine-125 and iodine-123. Radiat Res 2006; 165:688-94.

Wang K, Chen K, Kassis AI. Crystal structure of 2-(2’-hydroxyphenyl)-6-tributylstannyl-4-(3H)-quinazolinone and 2-(2’-hydroxyphenyl)-6-iodo-4-(3H)-quinazolinone. Cryst Res

            Technol 2006; 41:622-7.

Barcellos-Hoff, MH, Chaudhry MA, De Veaux L, Geard C, Kadhim M, Kassis A, Little JB, Maissen A, Mitchel R, Morgan BF, Mosse I, Müller W, Newman DJ, Nikjoo H, Niwa O, Prise K, Redpath L, Sáfrány G, Sakai K, Schofield P, Resat MS, Springer D, Stanbridge E, Suzuki K, Waker T, Wright EG, Yuan Z-M, Quinn J, Rainbow A, Rollo D, Seymour C, Mothersill C, Boreham D. Meeting report: Radiation-induced genomic instability and bystander effects; implications for evolutionary biology, report on an international workshop on radiation-induced low-dose effects held at McMaster University in Hamilton, Ontario, Canada, October 28–November 1, 2004. Radiat Res 2005; 163:473-6.

Kassis AI. Radiotargeting agents for cancer therapy. Expert Opin Drug Deliv 2005; 2:981-91.

Kassis AI, Adelstein SJ. Radiobiologic principles in radionuclide therapy. J Nucl Med 2005; 46(Suppl 1):4S-12S.

Chen K, Adelstein SJ, Kassis AI. (2E)-2-(3,5-dimethoxyphenyl)-3-(4-ethoxy-3-iodophenyl)acrylic acid. Acta Crystallogr 2005; E61:o3517–o3519.

Safaie Semnani E, Wang K, Adelstein SJ, Kassis AI. 5-[123I/125I]iodo-2’-deoxyuridine in metastatic lung cancer: radiopharmaceutical formulation affects targeting. J Nucl Med 2005; 46:800-6.

Kassis AI. The amazing world of Auger electrons. Int J Radiat Biol 2004; 80:789-803.

Kassis AI. In vivo validation of the bystander effect. Hum Exp Toxicol 2004; 23:71-3.

Kassis AI, Kirichian AM, Wang K, Safaie Semnani E, Adelstein SJ. Therapeutic potential of 5-[125I]iodo-2’-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis. Int J Radiat Biol 2004; 80:941-6.

Chen K, Adelstein SJ, Kassis AI. Molecular simulation of ligand-binding with DNA: implications for 125I-labeled pharmaceutical design. Int J Radiat Biol 2004; 80:921-6.

Urashima T, Wang K, Adelstein SJ, Kassis AI. Activation of diverse pathways to apoptosis by 125IdUrd and g-photon exposure. Int J Radiat Biol 2004; 80:867-74.

Chen K, Adelstein SJ, Kassis AI. Molecular modeling of the interaction of iodinated Hoechst analogs with DNA: implications for new radiopharmaceutical design. J Mol Struct (Theochem) 2004; 711:49-56.

Kassis AI. In-vivo validation of the bystander effect. BELLE Newslett 2003; 11(3):10-2.

Bodei L, Kassis AI, Adelstein SJ, Mariani G. Radionuclide therapy with iodine-125 and other Auger-electron-emitting radionuclides: experimental models and clinical applications [update]. Cancer Biother Radiopharm 2003; 18:861-77.

Adelstein SJ, Kassis AI, Bodei L, Mariani G. Radiotoxicity of iodine-125 and other Auger-electron-emitting radionuclides: background to therapy [update]. Cancer Biother Radiopharm 2003; 18:301-16.

Kassis AI. Invited commentary: Cancer therapy with Auger electrons: are we almost there? J Nucl Med 2003; 44:1479-81.

Kassis AI, Adelstein SJ. Considerations in the selection of radionuclides for cancer therapy. In: Welch MJ, Redvanly CS, eds. Handbook of radiopharmaceuticals: radiochemistry and applications. Chichester: John Wiley and Sons, 2003:767-93.

Kassis AI. Radiobiology aspects and radionuclide selection criteria in cancer therapy. In: Zaidi H, Sgouros G, eds. Therapeutic applications of Monte Carlo calculations in nuclear medicine. Bristol: Institute of Physics Publishing, 2003:175-201.

Xue LY, Butler NJ, Makrigiorgos GM, Adelstein SJ, Kassis AI. Bystander effect produced by radiolabeled tumor cells in vivo. Proc Natl Acad Sci USA 2002; 99:13765-70.

Ho N, Harapanhalli RS, Dahman BA, Chen K, Wang K, Adelstein SJ, Kassis AI. Synthesis and biologic evaluation of a radioiodinated quinazolinone derivative for enzyme-mediated insolubilization therapy. Bioconjugate Chem 2002; 13:357-64.

Kundra V, Mannting F, Jones AG, Kassis AI. Noninvasive monitoring of somatostatin receptor type 2 chimeric gene transfer. J Nucl Med 2002; 43:406-12.

Ho N, Tumeh PC, Kassis AI. Synthesis and biologic studies of iodinated (125I/127I) ethidium. Nucl Med Biol 2001; 28:983-90.

Walicka MA, Adelstein SJ, Kassis AI. Chemical modification of 5-[125I]iodo-2'-deoxyuridine toxicity in mammalian cells in vitro. Int J Radiat Biol 2001; 77:625-30.

Mariani G, Bodei L, Adelstein SJ, Kassis AI. Invited commentary: Emerging roles for radiometabolic therapy of tumors based on Auger electron emission. J Nucl Med 2000; 41:1519-21.

Kassis AI, Dahman BA, Adelstein SJ. In vivo therapy of neoplastic meningitis with methotrexate and 5-[125I]iodo-2'-deoxyuridine. Acta Oncol 2000; 39:731-7.

Kassis AI, Walicka MA, Adelstein SJ. Double-strand break yield following 125I decay: effects of DNA conformation. Acta Oncol 2000; 39:721-6.

Walicka MA, Ding Y, Adelstein SJ, Kassis AI. Toxicity of DNA-incorporated iodine-125: quantifying the direct and indirect effects. Radiat Res 2000; 154:326-30. Erratum, Radiat Res 2000; 154:608.

Walicka MA, Ding Y, Adelstein SJ, Kassis AI. Morphological transformation of C3H 10T1/2 cells by 99mTc-Cardiolite. J Nucl Med 2000; 41:1545-51.

Walicka MA, Ding Y, Roy AM, Harapanhalli RS, Adelstein SJ, Kassis AI. Cytotoxicity of [125I]iodoHoechst 33342: contribution of scavengeable effects. Int J Radiat Biol 1999; 75:1579-87.

Kassis AI, Harapanhalli RS, Adelstein SJ. Strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125: direct compared to indirect effects. Radiat Res 1999; 152:530-8.

Kassis AI, Harapanhalli RS, Adelstein SJ. Comparison of strand breaks in plasmid DNA after positional changes of Auger-electron-emitting iodine-125. Radiat Res 1999; 151:167-76.

Maulik G, Kassis AI, Savvides P, Makrigiorgos GM. Fluoresceinated phosphoethanolamine for flow-cytometric measurement of lipid peroxidation. Free Radic Biol Med 1998; 25:645-53.

Walicka MA, Vaidyanathan G, Zalutsky MR, Adelstein SJ, Kassis AI. Survival and DNA damage in Chinese hamster V79 cells exposed to alpha particles emitted by DNA-incorporated astatine-211. Radiat Res 1998; 150:263-8.

Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PMcL, Adelstein SJ. 5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats. J Nucl Med 1998; 39:1148-54.

Harapanhalli RS, Roy AM, Adelstein SJ, Kassis AI. [125I/127I/131I]iodorhodamine: synthesis, cellular localization, and biodistribution in athymic mice bearing human tumor xenografts and comparison with [99mTc]hexakis(2-methoxyisobutylisonitrile). J Med Chem 1998; 41:2111-7.

Harapanhalli RS, Matalka KZ, Jones PL, Mahmood A, Adelstein SJ, Kassis AI. Lysine-directed conjugation of ethidium homodimer to B72.3 antibody: retention of immunoreactivity but altered tumor targeting. Nucl Med Biol 1998; 25:267-78.

Chakrabarti S, Kassis AI, Slayter HS, Bump EA, Sahu SK, Makrigiorgos GM. Continuous detection of radiation or metal generated hydroxyl radicals within core chromatin particles. Int J Radiat Biol 1998; 73:53-63.

Walicka MA, Adelstein SJ, Kassis AI. Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: clonogenic survival. Radiat Res 1998; 149:142-6.

Walicka MA, Adelstein SJ, Kassis AI. Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: double-strand breaks. Radiat Res 1998; 149:134-41.

Harapanhalli RS, Matalka KZ, Jones PL, Mahmood A, Adelstein SJ, Kassis AI. Lysine-directed conjugation of ethidium homodimer to B72.3 mAb: retention of immunoreactivity and altered tumor targeting. Radiochim Acta 1997; 79:77-82.

Harapanhalli RS, Adelstein SJ, Kassis AI. Site-specific conjugation of ethidium homodimer to B72.3 mAb: retention of immunoreactivity, isoelectric point and in vivo tumor targeting. Radiochim Acta 1997; 79:73-6.

Anderson LL, Lau CC, Gracely EJ, Berkowitz RS, Kassis AI. Enhancement of 131I-mediated cytotoxicity by caffeine. Gynecol Oncol 1997; 65:253-7.

Sahu SK, Wen PYC, Foulon CF, Nagel JS, Black PMcL, Adelstein SJ, Kassis AI. Intrathecal 5-[125I]iodo-2'-deoxyuridine in a rat model of leptomeningeal metastases. J Nucl Med 1997; 38:386-90.

Sahu SK, Kortylewicz ZP, Baranowska-Kortylewicz J, Taube RA, Adelstein SJ, Kassis AI. Strand breaks after the decay of iodine-125 in proximity to plasmid pBR322 DNA. Radiat Res 1997; 147:401-8.

Makrigiorgos GM, Kassis AI, Mahmood A, Bump EA, Savvides P. Novel fluorescein-based flow-cytometric method for detection of lipid peroxidation. Free Radic Biol Med 1997; 22:93-100.

Kassis AI as workshop participant. In: Feinendegen LE, McClure JJ, eds. Workshop on alpha-emitters for medical therapy, Denver, CO, May 1996. Germantown, MD: Department of Energy, 1996.

Kassis AI, Adelstein SJ, Mariani G. Radiolabeled nucleoside analogs in cancer diagnosis and therapy. Q J Nucl Med 1996; 40:301-19.

Mariani G, Di Sacco S, Bonini R, Di Luca L, Buralli S, Bonora D, Ricci S, Baranowska-Kortylewicz J, Adelstein SJ, Falcone A, Kassis AI. Biochemical modulation by 5-fluorouracil and l-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer. Acta Oncol 1996; 35:941-5.

Kassis AI, Adelstein SJ. 5-[125I]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats. Acta Oncol 1996; 35:935-9.

Adelstein SJ, Kassis AI. Strand breaks in plasmid DNA following positional changes of Auger-electron-emitting radionuclides. Acta Oncol 1996; 35:797-801.

Makrigiorgos GM, Bump E, Kassis AI. Molecular dosimetry of radiation induced free radicals using a chromatin-incorporated fluorescent molecule. In: Giakoumakis E, Anagnostakis MJ, Petropoulos NP, eds. Proceedings First Mediter Conf Radiat Prot, Athens, Greece, 1994. Athens, Greece: National Technical University, 1996:25-35.

Mariani G, Di Sacco S, Volterrani D, Di Luca L, Buralli S, Di Stefano R, Baranowska-Kortylewicz J, Bonora D, Matteucci F, Ricci S, Bellina CR, Falcone A, Salvadori PA, Mosca F, Adelstein SJ, Kassis AI. Tumor targeting by intra-arterial infusion of 5-[123I]-iodo-2'-deoxyuridine in patients with liver metastases from colorectal cancer. J Nucl Med 1996; 37(4, suppl):22S-25S.

Kassis AI, Tumeh SS, Wen PYC, Baranowska-Kortylewicz J, Van den Abbeele AD, Zimmerman RE, Carvalho PA, Garada BM, DeSisto WC, Bailey NO, Castronovo FP Jr, Mariani G, Black PMcL, Adelstein SJ. Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patient with a brain tumor. J Nucl Med 1996; 37(4, suppl):19S-22S.

Mariani G, Collecchi P, Baldassarri S, Di Luca L, Buralli S, Fontanini G, Baranowska-Kortylewicz J, Adelstein SJ, Kassis AI. Tumor uptake and mitotic activity pattern of 5-[125I]iodo-2'-deoxyuridine after intravesical infusion in patients with bladder cancer. J Nucl Med 1996; 37(4, suppl):16S-19S.

Kassis AI, Adelstein SJ. Preclinical animal studies with radioiododeoxyuridine. J Nucl Med 1996; 37(4, suppl):10S-12S.

Foulon CF, Adelstein SJ, Kassis AI. Kit formulation for the preparation of radiolabeled

            iododeoxyuridine by demetallation. J Nucl Med 1996; 37(4, suppl):1S-3S.

Kassis AI, Adelstein SJ. Preface to Radiolabeled IUdr, proceedings of symposium on clinical applications of radiolabeled IUdR. J Nucl Med 1996; 37(4, suppl).

Harapanhalli RS, McLaughlin LW, Howell RW, Rao DV, Adelstein SJ, Kassis AI. [125I/127I]iodoHoechst 33342: synthesis, DNA binding, and biodistribution. J Med Chem 1996; 39:4804-9.

Chakrabarti S, Mahmood A, Kassis AI, Bump EA, Jones AG, Makrigiorgos GM. Generation of hydroxyl radicals by nucleohistone-bound metal–adriamycin complexes. Free Radic Res 1996; 25:207-20.

Foulon CF, Adelstein SJ, Kassis AI. One-step synthesis of radioiodinated biotin derivatives. Bioorg Med Chem Lett 1996; 6:779-84.

Chakrabarti S, Makrigiorgos GM, O'Brien K, Bump E, Kassis AI. Measurement of hydroxyl radicals catalyzed in the immediate vicinity of DNA by metal–bleomycin complexes. Free Radic Biol Med 1996; 20:777-83.

Kassis AI, Jones PL, Matalka KZ, Adelstein SJ. Antibody-dependent signal amplification in tumor xenografts after pretreatment with biotinylated monoclonal antibody and avidin or streptavidin. J Nucl Med 1996; 37:343-52.

Van den Abbeele AD, Tutrone RF, Berman RM, Baranowska-Kortylewicz J, Barclay PD, Richie JP, Adelstein SJ, Kassis AI. Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer. J Nucl Med 1996; 37:315-20.

Muto MG, Kassis AI. Monoclonal antibodies used in the detection and treatment of epithelial ovarian cancer. Cancer 1995; 76:2016-27.

Adelstein SJ, Kassis AI. Radiobiology. In: Wagner HN Jr, Szabo Z, Buchanan JW, eds. Principles of nuclear medicine. Second edition. Philadelphia: WB Saunders Company, 1995:95-105.

Foulon CF, Zhang YZ, Adelstein SJ, Kassis AI. Instantaneous preparation of radiolabeled 5-iodo-2'-deoxyuridine. Appl Radiat Isot 1995; 46:1039-46.

Gangopadhyay A, Saravis CA, Van den Abbeele AD, Kassis AI. pI-dependent isolation of antibody isoforms by semipreparative isoelectric focusing. Q J Nucl Med 1995; 39:129-33.

Makrigiorgos GM, Bump E, Huang C, Baranowska-Kortylewicz J, Kassis AI. A fluorimetric method for the detection of copper-mediated hydroxyl free radicals in the immediate proximity of DNA. Free Radic Biol Med 1995; 18:669-78.

Sahu SK, Kassis AI, Makrigiorgos GM, Baranowska-Kortylewicz J, Adelstein SJ. The effects of indium-111 decay on pBR322 DNA. Radiat Res 1995; 141:193-8.

Mariani G, Di Sacco S, Volterrani D, Matteucci F, Di Luca L, Buralli S, Baranowska-Kortylewicz J, Di Stefano R, Ricci S, Bellina CR, Falcone A, Salvadori PA, Mosca F, Adelstein SJ, Kassis AI. Tumor targeting with 5-[123I]iodo-2'-deoxyuridine infused into the hepatic artery of patients with liver metastases from colorectal cancer. J Nucl Biol Med 1994; 38:265-6.

Kassis AI. Toxicity and therapeutic effects of low-energy electrons. Nucl Instr Meth Phys Res B 1994; 87:279-84.

Charlton DE, Kassis AI, Adelstein SJ. A comparison of experimental and calculated survival curves for V79 cells grown as monolayers or in suspension exposed to alpha irradiation from 212Bi distributed in the growth medium. Radiat Prot Dosimetry 1994; 52:311-5.

Kortylewicz ZP, Baranowska-Kortylewicz J, Adelstein SJ, Carmel AD, Kassis AI. Radiolabeled biotin amides from triazenyl precursors: synthesis, binding, and in-vivo properties. J Labelled Comp Radiopharm 1994; 34:1129-46.

Howell RW, Kassis AI, Adelstein SJ, Rao DV, Wright HA, Hamm RN, Turner JE, Sastry KSR. Radiotoxicity of platinum-195m-labeled trans-platinum(II) in mammalian cells. Radiat Res 1994; 140:55-62.

Makrigiorgos GM, Bump E, Huang C, Baranowska-Kortylewicz J, Kassis AI. Accessibility of nucleic acid-complexed biomolecules to hydroxyl radicals correlates with their conformation: a fluorescence polarization spectroscopy study. Int J Radiat Biol 1994; 66:247-57.

Gangopadhyay A, Van den Abbeele AD, Kassis AI. Modification of mouse IgG isoelectric point following radioiodination. Antibody Immunoconj Radiophar 1994; 7:171-8.

Gangopadhyay A, Saravis CA, Kassis AI. Semipreparative isoelectrophoresis of DTPA-conjugated antibody leads to isolation of antibody isoforms with different immunoreactivities. J Nucl Biol Med 1994; 38:61-7.

Makrigiorgos GM, Folkard M, Huang C, Bump E, Baranowska-Kortylewicz J, Sahu SK, Michael BD, Kassis AI. Quantification of radiation-induced hydroxyl radicals within nucleohistones using a molecular fluorescent probe. Radiat Res 1994; 138:177-85.

Mariani G, Di Sacco G, Matteucci F, Volterrani D, Baranowska-Kortylewicz J, Ricci S, Di Stefano R, Troiani R, Di Luca L, Falcone A, Bellina CR, Salvadori PA, Conte PF, Sicari A, Mosca F, Adelstein SJ, Kassis AI. Intra-arterial infusion of 5-[123I]iodo-2'-deoxyuridine in patients with liver metastases from colon cancer. J Nucl Biol Med 1993; 37:157-8.

Mariani G, Giuliani L, Baranowska-Kortylewicz J, Collecchi P, Meucci G, Di Luca L, Viacava P, Van den Abbeele AD, Bevilacqua G, Salvadori PA, Adelstein SJ, Kassis AI. Intratumoral injection of 5-[125I]iodo-2'-deoxyuridine in patients with breast cancer. In: Hofer R, Bergmann H, Sinzinger H, eds. Radioactive isotopes in clinical medicine and research. Stuttgart: Schattauer Verlag, 1993:188-93.

Weber DA, Kassis AI. Co-editors preface. Special Supplement of Medical Physics on radiolabeled antibody tumor dosimetry. Med Phys 1993; 20:497.

Kassis AI, Adelstein SJ. Therapeutic potential of internally administered radionuclides. In: Black PMcL, Schoene WC, Lampson LA, eds. Contemporary issues in neurological surgery. Astrocytomas: diagnosis, treatment, and biology. Boston, MA: Blackwell Scientific Publications, 1993:290-9.

Speidel MT, Holmquist B, Kassis AI, Humm JL, Berman RM, Atcher RW, Hines JJ, Macklis RM. Morphological, biochemical, and molecular changes in endothelial cells following alpha-particle irradiation. Radiat Res 1993; 136:373-81.

Mariani G, Collecchi P, Giuliani L, Baranowska-Kortylewicz J, Di Luca L, Meucci G, Viacava P, Van den Abbeele AD, Salvadori PA, Di Sacco S, Adelstein SJ, Bevilacqua G, Kassis AI. Tumor targeting potential and metabolism of 5-[125I]iodo-2'-deoxyuridine injected intratumorally in patients with breast cancer. Ann NY Acad Sci 1993; 698:204-11.

Baranowska-Kortylewicz J, Kassis AI. Labeling of sulfhydryl groups in intact mammalian cells with coumarins. Bioconjugate Chem 1993; 4:305-7.

Baranowska-Kortylewicz J, Kassis AI. Labeling of immunoglobulins with bifunctional, sulfhydryl-selective, and photoreactive coumarins. Bioconjugate Chem 1993; 4:300-4.

Mariani G, Cei A, Collecchi P, Baranowska-Kortylewicz J, Van den Abbeele AD, Di Luca L, Di Stefano R, Viacava P, Ferdeghini EM, Di Sacco S, Salvadori PA, Bevilacqua G, Adelstein SJ, Mosca F, Kassis AI. Tumor targeting in vivo and metabolic fate of 5-[iodine-125]iodo-2'-deoxyuridine following intratumoral injection in patients with colorectal cancer. J Nucl Med 1993; 34:1175-83.

Makrigiorgos GM, Baranowska-Kortylewicz J, Bump E, Sahu SK, Berman RM, Kassis AI. A method for detection of hydroxyl radicals in the vicinity of biomolecules using radiation-induced fluorescence of coumarin. Int J Radiat Biol 1993; 63:445-58.

Kinsey BM, Kassis AI. Synthesis and biological activity of 125I/127I-phenylboronic acid derivatives. Nucl Med Biol 1993; 20:13-22.

Mariani G, Cei A, Giuliani L, Baranowska-Kortylewicz J, Collecchi P, Di Stefano R, Di Lucca L, Viacava P, D'Elia F, Guadagni A, Meucci G, Salvadori PA, Van den Abbeele AD, Bevilacqua G, Mosca F, Adelstein SJ, Kassis AI. Tumor targeting potential and metabolism of 5-[125I]iodo-2'-deoxyuridine injected intratumorally in patients with gastrointestinal or breast cancers. J Nucl Biol Med 1992; 36:154-7.

Van den Abbeele AD, Baranowska-Kortylewicz J, Adelstein SJ, Carvalho PA, Tutrone RF, Richie JP, Wen PYC, Black PMcL, Mariani G, Kassis AI. Diagnostic and therapeutic applications of Auger-electron-emitting 5-[123I/125I]iodo-2'-deoxyuridine in cancer. In: Howell RW, Narra VR, Sastry KSR, Rao DV, eds. Biophysical aspects of Auger processes, Am Assoc Physicists Med Symp Proceedings No 8. Woodbury, NY: American Institute of Physics, 1992:372-95.

Nagasawa H, Kassis AI, Berman RM, Sahu SK, Nickoloff JA, Okinaka RT, Adelstein SJ, Little JB. Comparison of mutation induction by external and internal radiation sources in synchronized Chinese hamster ovary (CHO) cells. In: Howell RW, Narra VR, Sastry KSR, Rao DV, eds. Biophysical aspects of Auger processes, Am Assoc Physicists Med Symp Proceedings No 8. Woodbury, NY: American Institute of Physics, 1992:194-209.

Kassis AI. Editorial: The MIRD approach: remembering the limitations. J Nucl Med 1992; 33:781-2.

Kassis AI, Adelstein SJ. Editorial: Does nonuniformity of dose have implications for radiation protection? J Nucl Med 1992; 33:384-7.

Kassis AI. Dosimetric aspects of administered radionuclides. In: Carpi A, Sagripanti A, Mittermayer Ch, eds. Progress in clinical oncology. Munchen: Sympomed Medical Publishers, 1992:112-24.

Muto MG, Finkler NJ, Kassis AI, Howes AE, Anderson LL, Lau CC, Zurawski VR Jr, Weadock K, Tumeh SS, Lavin P, Knapp RC. Intraperitoneal radioimmunotherapy of refractory ovarian carcinoma utilizing iodine-131-labeled monoclonal antibody OC125. Gynecol Oncol 1992; 45:265-72.

Khawli LA, Kassis AI. m-[125I]iodoaniline: a useful reagent for radiolabeling biotin. Nucl Med Biol 1992; 19:297-301.

Khawli LA, Van den Abbeele AD, Kassis AI. N-(m-[125I]­iodophenyl)maleimide: an agent for high yield radiolabeling of antibodies. Nucl Med Biol 1992; 19:289-95.

Makrigiorgos GM, Berman RM, Baranowska-Kortylewicz J, Bump E, Humm JL, Adelstein SJ, Kassis AI. DNA damage produced in V79 cells by DNA-incorporated iodine-123: a comparison with iodine-125. Radiat Res 1992; 129:309-14.

Kassis AI. Editorial: Optimizing antibodies for use in nuclear medicine. J Nucl Med 1991; 32:1751-3.

Adelstein SJ, Kassis AI, Baranowska-Kortylewicz J, Van den Abbeele AD, Mariani G, Ito S. Potential for tumor therapy with iodine-125 labeled immunoglobulins. Nucl Med Biol 1991; 18:43-4.

Kassis AI, Guptill WE, Taube RA, Adelstein SJ. Radiotoxicity of 5-[125I]iodo-2'-deoxyuridine in mammalian cells following treatment with 5-fluoro-2'-deoxyuridine. J Nucl Biol Med 1991; 35:167-73.

Baranowska-Kortylewicz J, Makrigiorgos GM, Van den Abbeele AD, Berman RM, Adelstein SJ, Kassis AI. 5-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model. Int J Radiat Oncol Biol Phys 1991; 21:1541-51.

Van den Abbeele AD, Aaronson RA, Daher S, Taube RA, Adelstein SJ, Kassis AI. Antigen-binding site protection during radiolabeling leads to a higher immunoreactive fraction. J Nucl Med 1991; 32:116-22.

Mariani G, Ito S, Nayak RC, Baranowska-Kortylewicz J, Venkateshan CN, Van den Abbeele AD, Eisenbarth GS, Adelstein SJ, Kassis AI. Capping and internalization of monoclonal antibody-surface antigen complex: a possible mode of interaction of monoclonal antibodies and tumor cells. J Nucl Biol Med 1991; 35:111-9.

Tumeh SS, Carvalho PA, Van den Abbeele AD, Maguire JH, Rauh DA, Neptune M, Kassis AI. Detection of focal infection by 111In-human polyclonal IgG. J Nucl Biol Med 1991; 35:4-9.

Janicek MJ, Van den Abbeele AD, DeSisto WC, Kassis AI, Holman BL, Tumeh SS, Hollenberg NK. Embolization of platelets after endothelial injury to the aorta in rabbits: assessment with 111indium-labeled platelets and angiography. Invest Radiol 1991; 26:655-9.

Mariani G, Kassis AI, Adelstein SJ. Antibody internalization by tumor cells: implications for tumor diagnosis and therapy. J Nucl Med Allied Sci 1990; 34:51-5.

Kassis AI, Makrigiorgos GM, Adelstein SJ. Dosimetric considerations and therapeutic potential of Auger electron emitters. In: Adelstein SJ, Kassis AI, Burt RW, eds. Frontiers in nuclear medicine: dosimetry of administered radionuclides, proceedings of symposium, Washington, DC, 1989. Washington: American College of Nuclear Physicians, 1990:257-74.

Makrigiorgos GM, Adelstein SJ, Kassis AI. Limitations of MIRD at the cellular level. In: Adelstein SJ, Kassis AI, Burt RW, eds. Frontiers in nuclear medicine: dosimetry of administered radionuclides, proceedings of symposium, Washington, DC, 1989. Washington: American College of Nuclear Physicians, 1990:44-57.

Adelstein SJ, Kassis AI. Preface. In: Adelstein SJ, Kassis AI, Burt RW, eds. Frontiers in nuclear medicine: dosimetry of administered radionuclides, proceedings of symposium, Washington, DC, 1989. Washington: American College of Nuclear Physicians, 1990:v-xi.

Kassis AI. 5-(123I/125I)iodo-2'-deoxyuridine for cancer diagnosis and therapy. J Nucl Med Allied Sci 1990; 34:299-303.

Makrigiorgos G, Adelstein SJ, Kassis AI. Auger electron emitters: insights gained from in vitro experiments. Radiat Environ Biophys 1990; 29:75-91.

Van den Abbeele AD, Aaronson RA, Taube RA, Adelstein SJ, Kassis AI. Preadsorption of radiolabeled monoclonal antibodies to liver and spleen tissues leads to higher tumor-to-normal-tissue ratios. J Nucl Med Allied Sci 1990; 34:94-102.

Whaley JM, Kassis AI, Kinsey BM, Adelstein SJ, Little JB. Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. Int J Radiat Biol 1990; 57:1087-103.

Muto GM, Finkler NJ, Kassis AI, Lepisto EM, Knapp RC. Human anti-murine antibody responses in ovarian cancer patients undergoing radioimmunotherapy with the murine monoclonal antibody OC-125. Gynecol Oncol 1990; 38:244-8.

Makrigiorgos GM, Baranowska-Kortylewicz J, Van den Abbeele AD, Ito S, Vinter DW, Adelstein SJ, Kassis AI. Microscopic spatial inhomogeneity of radiopharmaceutical deposition in mammalian tissues: dosimetry at the cellular level and comparison with conventional dosimetry. Radiat Prot Dosimetry 1990; 31:319-24.

Makrigiorgos GM, Waker AJ, Kassis AI. Microdosimetric characterisation of radiation fields with a high pressure ionisation chamber: a comparison with the low pressure proportional counter. Radiat Prot Dosimetry 1990; 31:161-5.

Makrigiorgos GM, Ito S, Baranowska-Kortylewicz J, Vinter DW, Iqbal A, Van den Abbeele AD, Adelstein SJ, Kassis AI. Inhomogeneous deposition of radiopharmaceuticals at the cellular level: experimental evidence and dosimetric implications. J Nucl Med 1990; 31:1358-63.

Makrigiorgos GM, Adelstein SJ, Kassis AI. Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates. JAMA 1990; 264:592-5.

Livni E, Ito S, Kassis AI, Elmaleh DR. (3H/14C)beta-methylheptadecanoic acid subcellular distribution and lipid incorporation in mouse heart. Lipids 1990; 25:238-40.

Kinsey BM, Fayad F, Venkateshan CN, Adelstein SJ, Kassis AI. Synthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine. Nucl Med Biol 1990; 17:341-6.

Kassis AI, Van den Abbeele AD, Wen PYC, Baranowska-Kortylewicz J, Aaronson RA, DeSisto WC, Lampson LA, Black PMcL, Adelstein SJ. Specific uptake of the Auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnostic and therapeutic implications in humans. Cancer Res 1990; 50:5199-203.

Kassis AI, Makrigiorgos GM, Adelstein SJ. Implications of radiobiological and dosimetric studies of DNA-incorporated 123I: the use of the Auger effect as a biological probe at the nanometre level. Radiat Prot Dosimetry 1990; 31:333-8.

Janicek MJ, Van den Abbeele AD, Hollenberg NK, Kassis AI, Holman BL, Tumeh SS. Platelet activation and aggregation after endothelial injury: assessment with indium-111-labeled platelets and angiography. Invest Radiol 1990; 25:988-93.

Baranowska-Kortylewicz J, Berman RM, Kaldany A, Eisenbarth GS, Kassis AI. Immunoradiometric assay for antibodies recognizing antigenic gangliosides. J Nucl Med Allied Sci 1990; 34:34-41.

Baranowska-Kortylewicz J, Adelstein SJ, Kassis AI. 5-Iodo-2'-deoxyuridine-protein conjugates: synthesis and enzymatic degradation. Sel Cancer Ther 1990; 6:1-13.

Mariani G, Van den Abbeele AD, Venkateshan CN, Kaldany A, Ito S, Adelstein SJ, Kassis AI. Internalization of monoclonal 3G5-IgM by a rat insulinoma cell line. Nuklearmedizin 1989; Suppl 25:602-5.

Weadock KS, Anderson LL, Kassis AI. A simple remote system for the high-level radioiodination of monoclonal antibodies. J Nucl Med Allied Sci 1989; 33:37-41.

Adelstein SJ, Kassis AI. Radiobiology of alpha particle and Auger electron emitters. In: DeNardo GL, Lewis JP, Raventos A, Burt RW, eds. Frontiers in nuclear medicine: biology of radionuclide therapy, proceedings of symposium, Washington, DC, 1988. Washington: American College of Nuclear Physicians, 1989:252-61.

Weber DA, Eckerman KF, Dillman LT, Ryman JC, in collaboration with Atkins HL, Budinger TF, Kassis AI, Lathrop KA, Loevinger R, Marcus CS, Poston JW, Robertson JS, Siegel JA, Thomas SR, Watson EE. MIRD: radionuclide data and decay schemes. New York: The Society of Nuclear Medicine, 1989.

Muto MG, Lepisto EM, Van den Abbeele AD, Knapp RC, Kassis AI. Influence of human antimurine antibody on CA 125 levels in patients with ovarian cancer undergoing radioimmunotherapy or immunoscintigraphy with murine monoclonal antibody OC 125. Am J Obstet Gynecol 1989; 161:1206-12.

Makrigiorgos GM, Waker AJ, Kassis AI. Use of high pressure ionisation chambers and a comparison with TEPCs for obtaining microdosimetric information in unspecified radiation fields. Radiat Prot Dosimetry 1989; 29:15-9.

Makrigiorgos GM, Kassis AI, Baranowska-Kortylewicz J, McElvany KD, Welch MJ, Sastry KSR, Adelstein SJ. Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine. Radiat Res 1989; 118:532-44.

Makrigiorgos GM, Adelstein SJ, Kassis AI. Limitations of conventional internal dosimetry at the cellular level. J Nucl Med 1989; 30:1856-64.

Kinsey BM, Van den Abbeele AD, Adelstein SJ, Kassis AI. Absence of preferential uptake of [125I]iododihydrorhodamine 123 by four human tumor xenografts. Cancer Res 1989; 49:5986-8.

Khawli LA, Kassis AI. Synthesis of 125I labeled N-succinimidyl p-iodobenzoate for use in radiolabeling antibodies. Nucl Med Biol 1989; 16:727-33.

Mariani G, Van den Abbeele AD, Venkateshan CN, Kaldany A, Ito S, Adelstein SJ, Kassis AI. Monoclonal antibody internalization by tumor cells: an experimental model for potential radioimmunotherapy applications. Nucl Med Biol 1989; 16:147-50.

Kassis AI, Fayad F, Kinsey BM, Sastry KSR, Adelstein SJ. Radiotoxicity of an 125I-labeled DNA intercalator in mammalian cells. Radiat Res 1989; 118:283-94.

Finkler NJ, Muto MG, Kassis AI, Weadock K, Tumeh SS, Zurawski VR Jr, Knapp RC. Intraperitoneal radiolabeled OC 125 in patients with advanced ovarian cancer. Gynecol Oncol 1989; 34:339-44.

Sastry KSR, Howell RW, Rao DV, Mylavarapu VB, Kassis AI, Adelstein SJ, Wright HA, Hamm RN, Turner JE. Dosimetry of Auger emitters: physical and phenomenological approaches. In: Baverstock KF, Charlton DE, eds. DNA damage by Auger emitters. London: Taylor and Francis, Limited, 1988:27-38.

Kassis AI, Howell RW, Sastry KSR, Adelstein SJ. Positional effects of Auger decays in mammalian cells in culture. In: Baverstock KF, Charlton DE, eds. DNA damage by Auger emitters. London: Taylor and Francis, Limited, 1988:1-13.

Adelstein SJ, Kassis AI. Criteria for the selection of nuclides for radioimmunotherapy. In: Srivastava SC, ed. Radiolabeled monoclonal antibodies for imaging and therapy, Proceedings of the NATO Advanced Study Inst, Radiolabeled monoclonal antibodies for imaging and therapy: potential, problems and prospects, Castelvecchio Pascoli, Italy, 1986. New York: Plenum Publishing Corporation, 1988:165-76.

Van den Abbeele AD, Aaronson RA, Adelstein SJ, Kassis AI. Does the in vitro testing of the immunoreactivity of an antibody reflect its in vivo behavior? J Nucl Med Allied Sci 1988; 32:260-7.

Macklis RM, Kinsey BM, Kassis AI, Ferrara JLM, Atcher RW, Hines JJ, Coleman CN, Adelstein SJ, Burakoff SJ. Radioimmunotherapy with alpha-particle-emitting immunoconjugates. Science 1988; 240:1024-6.

Macklis RM, Kaplan WD, Ferrara JLM, Kinsey BM, Kassis AI, Burakoff SJ. Biodistribution studies of anti-Thy 1.2 IgM immunoconjugates: implications for radioimmunotherapy. Int J Radiat Oncol Biol Phys 1988; 15:383-9.

Kinsey BM, Macklis RM, Ferrara JM, Layne WW, Burakoff SJ, Kassis AI. Efficient conjugation of DTPA to an IgM monoclonal antibody in ascites fluid. Nucl Med Biol 1988; 15:285-92.

Kassis AI, Kinsey BM. Iodo-reduced rhodamine 123. Drugs Future 1988; 13:825-8.

Baranowska-Kortylewicz J, Kinsey BM, Layne WW, Kassis AI. Radioiododemercuration: a simple synthesis of 5-[123/125/127I]iodo-2'-deoxyuridine. Appl Radiat Isot 1988; 39:335-41.

Adelstein SJ, Kassis AI. Radiobiologic implications of the microscopic distribution of energy from radionuclides. Nucl Med Biol 1987; 14:165-9.

Kassis AI, Adelstein SJ, Bloomer WD. Therapeutic implications of Auger-emitting radionuclides. In: Spencer RP, Seevers RH Jr, Friedman AM, eds. Radionuclides in therapy. Boca Raton: CRC Press, 1987:119-34.

Layne WW, Kassis AI, Van den Abbeele A, Kinsey BM, Adelstein SJ. HPLC analysis of the dissociation and recombination of rabbit immunoglobulin G. J Immunol Methods 1987; 96:195-9.

Kinsey BM, Kassis AI, Fayad F, Layne WW, Adelstein SJ. Synthesis and biological studies of iodinated (127/125I) derivatives of rhodamine 123. J Med Chem 1987; 30:1757-61.

Kassis AI, Taube RA. Efficient radiolabeling of mammalian cells using 111In-tagged liposomes. Nucl Med Biol 1987; 14:33-5.

Kassis AI, Fayad F, Kinsey BM, Sastry KSR, Taube RA, Adelstein SJ. Radiotoxicity of 125I in mammalian cells. Radiat Res 1987; 111:305-18.

Kassis AI, Sastry KSR, Adelstein SJ. Kinetics of uptake, retention, and radiotoxicity of 125IUdR in mammalian cells: implications of localized energy deposition by Auger processes. Radiat Res 1987; 109:78-89.

Adelstein SJ, Kassis AI, Sastry KSR. Cellular vs. organ approaches to dose estimates. In: Schlafke-Stelson AT, Watson EE, eds. In: Proceedings Fourth Int Radiopharm Dosimetry Symp, Oak Ridge, TN, 1985, CONF-85113-(DE86010102). Oak Ridge: Oak Ridge Associated Universities, 1986:13-25.

Adelstein SJ, Bloomer WD, Kassis AI, Sastry KSR. The potential use of alpha and Auger-electron emitting radionuclides for therapy. In: Winkler C, ed. Nuclear medicine in clinical oncology. Berlin: Springer-Verlag, 1986:408-12.

Kassis AI, Harris CR, Adelstein SJ, Ruth TJ, Lambrecht R, Wolf AP. The in vitro radiobiology of astatine-211 decay. Radiat Res 1986; 105:27-36.

Huberman MS, Lokich JJ, Hill T, Kaldany A, Kassis A, Price T, Moore C, Davis S, Kasulis P, Monaco AP, Haagensen DE Jr. Non-human primate (baboon) anti-carcinoembryonic antigen antibody infusion in patients with metastatic adenocarcinoma: a phase I study. Cancer Immunol Immunother 1986; 23:137-42.

Kassis AI, Sastry KSR, Adelstein SJ. Intracellular localisation of Auger electron emitters: biophysical dosimetry. Radiat Prot Dosimetry 1985; 13:233-6.

Kassis AI, Adelstein SJ. Chemotoxicity of indium-111 oxine in mammalian cells. J Nucl Med 1985; 26:187-90.

Kassis AI, Sastry KSR, Adelstein SJ. Intracellular distribution and radiotoxicity of chromium-51 in mammalian cells: Auger-electron dosimetry. J Nucl Med 1985; 26:59-67.

Jones AG, Abrams MJ, Davison A, Brodack JW, Toothaker AK, Adelstein SJ, Kassis AI. Biological studies of a new class of technetium complexes: the hexakis(alkylisonitrile)technetium(I) cations. Int J Nucl Med Biol 1984; 11:225-34.

Kassis AI, Adelstein SJ, Haydock C, Sastry KSR, McElvany KD, Welch MJ. Radiotoxicity of Auger electrons in the DNA of mammalian cells: a comparison of 123I with 125I and 77Br. In: Broese JJ, Barendsen GW, Kal HB, Van der Kogel AJ, eds. Proceedings Seventh Int Congr Radiat Res, Session E, Dosimetry, radionuclides and technology. Amsterdam: Martinus Nijhoff Publishers, 1983:E5-07.

Kassis AI, Adelstein SJ, Haydock C, Sastry KSR. Thallium-201: an experimental and a theoretical radiobiological approach to dosimetry. J Nucl Med 1983; 24:1164-75.

Kassis AI, Adelstein SJ, Wolf AP, Fowler JG, Shiue C-Y. Transient toxicity of 2-deoxy-2-[18F]fluoro-D-glucose in mammalian cells: concise communication. J Nucl Med 1983; 24:1055-9.

Kassis AI, Adelstein SJ, Haydock C, Sastry KSR, McElvany KD, Welch MJ. Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells. Radiat Res 1982; 90:362-73.

Kassis AI, Adelstein SJ, Haydock C, Sastry KSR. Radiotoxicity of 75Se and 35S: theory and application to a cellular model. Radiat Res 1980; 84:407-25.

Kassis AI, Adelstein SJ. A rapid and reproducible method for the separation of cells from radioactive media. J Nucl Med 1980; 21:88-90.

Kassis AI, Warren KS, Mahmoud AAF. Antibody-dependent complement-mediated killing of schistosomula in intraperitoneal diffusion chambers in mice. J Immunol 1979; 123:1659-62.

Kassis AI, Warren KS, Mahmoud AAF. The Schistosoma haematobium egg granuloma. Cell Immunol 1978; 38:310-8.

Kassis AI, Aikawa M, Mahmoud AAF. Mouse antibody-dependent eosinophil and macrophage cell adherence and damage to schistosomula of Schistosoma mansoni. J Immunol 1978; 122:398-405.

Kassis AI, Tanner CE. Echinococcus multilocularis: complement's role in vivo in hydatid disease. Exp Parasitol 1977; 43:390-5.

Kassis AI, Tanner CE. Host serum proteins in Echinococcus multilocularis: activation via the classical complement pathway. Immunology 1977; 33:1-9.

Kassis AI, Tanner CE. Novel approach to the treatment of hydatid disease. Nature 1976; 262:588-9.

Kassis AI, Goh SL, Tanner CE. Lesions induced by complement in vitro on the protoscoleces of Echinococcus multilocularis: a study by electron microscopy. Int J Parasitol 1976; 6:199-211.

Kassis AI, Tanner CE. The role of complement in hydatid disease: in vitro studies. Int J Parasitol 1976; 6:25-35.

Kassis AI, Frayha GJ. Lipids of the cysticerci of Taenia hydatigena (Cestoda). Comp Biochem Physiol 1973; 46B:435-43.